Vampire: The Eternal Struggle is the customisable card game based on the role-playing game Vampire: The Masquerade, set in the World of Darkness game setting.

Vampire: The Eternal Struggle is a card game in which you take on the role of an ancient vampire, a Methuselah. For thousands of years you have lurked in the shadows of human societies, manipulating mortals and younger vampires. Your hunger for power knows no bounds, and you use whatever means possible to weaken your enemies, from subtle mischief to frontal assault. You must increase your influence and destroy the other Methuselahs one by one, before they destroy you.